Blood Clotting Affected By Warfarin

Blood Clotting Affected By Warfarin

Free Samples

Blood Clotting Affected By Warfarin

.cms-body-content table{width:100%!important;} #subhidecontent{ position: relative;
overflow-x: auto;
width: 100%;}

Blood Clotting Affected By Warfarin

0 Download5 Pages / 1,029 Words


Discuss about the Blood clotting affected by warfarin.


The clotting system involves a process where blood forms clots following a tissue injury to prevent further blood loss(Gee, 2018). The process follows a coagulation cascade where various clotting factors are involved(Gee, 2018). There are two major pathways of the coagulation which include the intrinsic and extrinsic pathways.  There are several coagulation factors that are involved in both pathways which include the tissue factor, factors XIII, XII, XI, X, IX, VIII, VII, V, IV, III, II and I(Tshikudi, Tripathi, Hajjarian, Van Cott & Nadkarni, 2017). Other important factors include calcium ions and vitamin K(Gee, 2018). Vitamin K is involved in activation of various coagulation factors. Warfarin work against as vitamin K hence it can inhibit the whole process resulting in homeostasis imbalance(Tshikudi, Tripathi, Hajjarian, Van Cott & Nadkarni, 2017).  
Blood clotting affected by warfarin
The blood clotting cascade is influenced by various clotting factors and cofactors. The cofactors are usually the inactive form of certain factors that activates various clotting factors into active forms(Palta, Saroa & Palta, 2014). Failure of this activation, no blood clotting can occur(Gee, 2018). Vitamin K is one of the cofactors used to activate the clotting factors X, IX, VII and II. An increased activation of vitamin K will lead to increase in clotting process and vise vasa(Gee, 2018).  
Therefore, VItamin K acts as an important contributing factor of the clotting process due to its effects on its dependent factors of the coagulation cascade(Goodman, Brunton, Chabner & Knollmann, 2012). This is due to the fact that, Vitamin K form one of the major factor that is required by the liver microsomal enzyme known as vitamin K epoxide reductase (VKOR) that catalyzes the conversion of the specific glutamyl precursors of the vitamin K clotting factors to gamma-carboxyl glutamyl residues in a plasma form of these proteins(Goodman, Brunton, Chabner & Knollmann, 2012). The product that comes from this carboxylation reaction is the 2, 3 eporoxide of Vitamin K quinone. Warfarin, which acts as the Vitamin K inhibitor is made up of the mixture of S- and R- enantiomers(Palta, Saroa & Palta, 2014).
The S- warfarin is usually the most active type of enantiomer than the R-warfarin. Both warfarin enantiomers inhibit the process of coagulation by blocking the enzymes encoded as VKORC1(Malátková, Sokolová, Chocholoušová Havlíková & Wsól, 2016). This, in turn, read to the reduction of peroxides of the vitamin K or oxidized vitamin K into an active coenzyme of the vitamin known as hydroquinone(Goodman, Brunton, Chabner & Knollmann, 2012). Since vitamin K serves a major cofactor of glutamyl carboxylase that serves as the catalyst in the carboxylation process of factors X, IX, VII and II, this characteristic of  Warfarin decreases the activity of all carboxylated clotting factors that are dependent on vitamin K(Harter, Levine & Henderson, 2015).
Calcium ions that usually activate prothrombin to thrombin normally function well in the presence of gamma carboxyl glutamyl in order to form des-gamma-carboxyl forms of prothrombin. Thereby, only the activated vitamin K can act as a cofactor in the conversion of prozymogens into zymogens capable of binding with calcium ions and smoothly interacting with phospholipids surfaces(Goodman, Brunton, Chabner & Knollmann, 2012). Therefore, the introduction of warfarin normally reduces the blood thrombotic potential as the needed factors are inactivated. The reduced vitamin K can be held back into normal through the intake of more vitamins K in the body and reduced dose of warfarin(Malátková, Sokolová, Chocholoušová Havlíková & Wsól, 2016). Below is the concept map that summarises the above whole process.
Summary Concept map
A summary concept map usually presents a relationship between various items and facts inform ofa diagram in order to show certain concepts of knowledge.
A concept map is meant to demonstrate an overall picture of a given topic by showing how various interacting subunits work to bring an overall outcome.
The diagram below demonstrate how warfarin affect the vitamin K  dependant factors of coagulation process therefore ending up affecting the clotting process.  

Concept Map and the disease

The impact of the disease process could be presented clearly be demonstrated on this concept map by introducing a personwith a fresh tissue injury for example.
After tissue injury, the body respondsto the clotting process to prevent further bleeding.
The clotting process involvesboth intrinsic and extrinsic pathways where various clotting factors are involved to enhance coagulation process.
Oxidized Vitamin K is involvedinactivation of clotting factors X, IX, VII and II, and proteins C and S of which play a key role in the clotting process.
The factors involved can be well be demonstrated by putting them in bold colorin order to show the exact stages of clotting process affected
Warfarin normally reducesoxidized vitamin K into its inactive form hence the clotting factors will not be activated. This, in turn, leads to more bleeding as the normal homeostasis is affected.

Gee, E. (2018). Principles and nursing management of anticoagulation. Nursing
Standard, 32(23), 50-63.
Goodman, L., Brunton, L., Chabner, B., & Knollmann, B. (2012). Goodman & Gilman’s
pharmacological basis of therapeutics. New York: McGraw-Hill.
Harter, K., Levine, M., & Henderson, S. (2015). Anticoagulation Drug Therapy: A
Review. Western Journal Of Emergency Medicine, 16(1), 11-17.
Malátková, P., Sokolová, S., Chocholoušová Havlíková, L., & Wsól, V. (2016). Carbonyl
reduction of warfarin: Identification and characterization of human warfarin reductases. Biochemical Pharmacology, 109, 83-90.
Palta, S., Saroa, R., & Palta, A. (2014). Overview of the coagulation system. Indian Journal Of
Anaesthesia, 58(5), 515.
Tshikudi, D., Tripathi, M., Hajjarian, Z., Van Cott, E., & Nadkarni, S. (2017). Optical sensing of
anticoagulation status: Towards point-of-care coagulation testing. PLOS ONE, 12(8),

Free Membership to World’s Largest Sample Bank

To View this & another 50000+ free samples. Please put
your valid email id.


Yes, alert me for offers and important updates


Download Sample Now

Earn back the money you have spent on the downloaded sample by uploading a unique assignment/study material/research material you have. After we assess the authenticity of the uploaded content, you will get 100% money back in your wallet within 7 days.

UploadUnique Document

DocumentUnder Evaluation

Get Moneyinto Your Wallet

Total 5 pages


*The content must not be available online or in our existing Database to qualify as

Cite This Work
To export a reference to this article please select a referencing stye below:


My Assignment Help. (2019). Blood Clotting Affected By Warfarin. Retrieved from

“Blood Clotting Affected By Warfarin.” My Assignment Help, 2019,

My Assignment Help (2019) Blood Clotting Affected By Warfarin [Online]. Available from:[Accessed 18 December 2021].

My Assignment Help. ‘Blood Clotting Affected By Warfarin’ (My Assignment Help, 2019) accessed 18 December 2021.

My Assignment Help. Blood Clotting Affected By Warfarin [Internet]. My Assignment Help. 2019 [cited 18 December 2021]. Available from:

.close{position: absolute;right: 5px;z-index: 999;opacity: 1;color: #ff8b00;}


Thank you for your interest
The respective sample has been mail to your register email id


$20 Credited
successfully in your wallet.
* $5 to be used on order value more than $50. Valid for
only 1

Account created successfully!
We have sent login details on your registered email.


Password: comes second to none as far customer support is concerned. Our customer executives offer round the clock assignment help assistance, and they clarify your doubts regarding accounting assignment help service. If you face any issues, just place your questions at, or call us. Our executives will even guide you through the application process.

Latest Nursing Samples

div#loaddata .card img {max-width: 100%;

NR510 Leadership And Role Of The Advanced Practice Nurse
Download :
0 | Pages :

Course Code: NR510
University: Chamberlain University is not sponsored or endorsed by this college or university

Country: United States

Advanced Professional Nurses (APNs) consist of nurses who are registered with proper training and have the required certificates that help them give healthcare skills in their place of work. APNs are very important since they make sure that those who need their attention are well attended to with accordance of each person’s needs (Sheer & Wong, 2008). The scarcity of healthcare experts, there is a reason to set …
Australia Bakersfield Management University of New South Wales Masters in Business Administration 

CNA741 Foundations Of Mental Health Nursing Theory 2
Download :
0 | Pages :

Course Code: CNA741
University: University Of Tasmania is not sponsored or endorsed by this college or university

Country: Australia

Electroconvulsive therapy (ECT) is the deliberate inducing of a modified generalized seizure in an anaesthetized patient under medically-controlled conditions to produce a therapeutic effect (Kavanagh & McLoughlin, 2009). To achieve this, an electric charge is passed through the brain between two electrodes that are placed on the scalp of the anaesthetized patient. Electroconvulsive therapy is used to cause changes in…
Australia Surry Hills Medical Healthcare University of New South Wales 

NUR2107 Person Centered Mental Health Care
Download :
0 | Pages :

Course Code: NUR2107
University: Monash University is not sponsored or endorsed by this college or university

Country: Australia

In Australia, the MHN reports that most cases of chronic mental illness are due depression: either socially or economically associated (Reich, 2015). Also, the bipolar condition and schizophrenia disorder have been on the increase up to the early 2000s after which the federal government is liaising with the MHN, and the state governments intervened through regulation of Medicare safety net and Medicare Levy (Dzipora and A…
Australia Clayton Management University of New South Wales Masters in Business Administration 

ITC542 Internetworking With TCP/IP
Download :
0 | Pages :

Course Code: ITC542
University: Charles Sturt University is not sponsored or endorsed by this college or university

Country: Australia

The advantages of larger MTU is:
They are appropriate for handling the transfer of the larger amount of the data that is set over the longer distance.
There is no major fragmentation important for fast delivery and few lost datagrams.
The advantages are for small MTU:
With good transferring of the time sensitive data like the audio or the video.
The suit for the multiplexing.
CSMA/CD is set with the operations wi…
Australia Brunswick Management industrial relations in Asia-pacific region  University of New South Wales Masters in Business Administration 

NURS11159 Introduction To Nursing
Download :
0 | Pages :

Course Code: NURS11159
University: Central Queensland University is not sponsored or endorsed by this college or university

Country: Australia

The The results of the Gallup’s Annual Honesty and Ethical Standards poll (DEC20, 2016) showed that nursing the most trusted profession for the 15th year all way. Trust is a firm belief, of the character, strength or truth of someone of something according to Merriam-Webster (1828). For a person to be trusted by anyone, he must have portrayed a particular character, trait, or individual strength. The character is also …
Australia Randwick Management University of New South Wales Masters in Business Administration 


Our Essay Writing Service Features

Qualified Writers
Looming deadline? Get your paper done in 6 hours or less. Message via chat and we'll get onto it.
We care about the privacy of our clients and will never share your personal information with any third parties or persons.
Free Turnitin Report
A plagiarism report from Turnitin can be attached to your order to ensure your paper's originality.
Safe Payments
The further the deadline or the more pages you order, the lower the price! Affordability is in our DNA.
No Hidden Charges
We offer the lowest prices per page in the industry, with an average of $7 per page
24/7/365 Support
You can contact us any time of day and night with any questions; we'll always be happy to help you out.
$15.99 Plagiarism report
$15.99 Plagiarism report
$15.99 Plagiarism report
$15.99 Plagiarism report
$3.99 Outline
$21.99 Unlimited Revisions
Get all these features for $65.77 FREE
Do My Paper

Frequently Asked Questions About Our Essay Writing Service

Academic Paper Writing Service

Our essay writers will gladly help you with:

Business Plan
Presentation or Speech
Admission Essay
Case Study
Reflective Writing
Annotated Bibliography
Creative Writing
Term Paper
Article Review
Critical Thinking / Review
Research Paper
Thesis / Dissertation
Book / Movie Review
Book Reviews
Literature Review
Research Proposal
Editing and proofreading
Find Your Writer

Latest Feedback From Our Customers

Customer ID:  # 678224
Research Paper
Highly knowledgeable expert, reasonable price. Great at explaining hard concerts!
Writer: Raymond B.
Customer ID: # 619634
Essay (any type)
Helped me with bear and bull markets right before my exam! Fast teacher. Would work with Grace again.
Writer: Lilian G.
Customer ID: # 519731
Research Paper
If you are scanning reviews trying to find a great tutoring service, then scan no more. This service elite!
Writer: Grace P.
Customer ID: #499222
Essay (any type)
This writer is great, finished very fast and the essay was perfect. Writer goes out of her way to meet your assignment needs!
Writer: Amanda B.
Place an Order

Calculate the price of your order

You will get a personal manager and a discount.
We'll send you the first draft for approval by at
Total price:

Powered by

× WhatsApp Us